In an insightful 42-minute interview, NMIN’s Scientific Director Dr. Pieter Cullis, a pioneer in liposomal gene and drug delivery, discusses his scientific career with a focus on his contributions to the evolution of gene therapy.
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The interview was conducted on behalf of the Gene Delivery and Gene Editing focus group of the Controlled Release Society (CRS) by Dr. Dominik Witzigmann, a postdoctoral fellow at the University of British Columbia and Operational Lead for NMIN’s NanoCore core facility.
Watch the full video above or click on a topic below to start watching the video at a specific point of the discussion.
A career journey: from undergraduate to post-doctoral studies at Oxford
From physics to nanomedicine: developing an interest in using lipids for drug delivery
From basic science to human health: the questions driving early research
Challenges for gene therapy: the need for well-characterized systems
Discoveries enabling clinical translation: steps toward developing ONPATTRO
Entrepreneurial spirit: motivation to found companies
Founding a company: challenges of running companies
Lipid nanoparticles - a breakthrough technology: developing ONPATTRO
Exciting future innovations: enabling gene therapies & gene editing
Barriers & challenges: going forward
Long-term toxicities: genome editing
Call to action: awareness of gene therapy
Collaborative efforts: working with government & industry
Young scientists can have an impact: opportunities
Rigorous characterization & the use of animal models
Multidisciplinary research & NMIN